Hyaluronic acid (HA) is a molecule naturally present in all connective tissues of the human body, which performs important physiological functions such as lubricating and protecting joint cartilage and moisturising the skin and mucous membranes.
IBSA Italy is the first and only company to have developed, in collaboration with the University of Campania, Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, hybrid formulations of hyaluronic acid thanks to the NAHYCO® HYBRID TECHNOLOGY, a patented thermal process that excludes the use of chemical reagents and leads to the formation of cooperative hybrid complexes.
The NAHYCO® HYBRID TECHNOLOGY combines high- and low-molecular-weight hyaluronic acid chains, both ultra-pure and biofermentative, in 3 operational steps:
- in the first step, a physiological solution containing 32 mg of high molecular weight hyaluronic acid (between 1,400 and 2,100 kDaltons) and 32 mg of low molecular weight hyaluronic acid (between 80 and 100 kDaltons) is prepared;
- in the second phase, thermal elevation causes the hydrogen bonds within the high and low molecular weight chains to break, allowing them to separate;
- in the third phase, the lowering of the temperature allows the formation of new hydrogen bonds between the low and high molecular weight hyaluronic acid chains, resulting in stable, chemically unmodified hyaluronic acid hybrid co-operative complexes.